ADM has released results from a clinical trial evaluating its Bifidobacterium animalis subsp. lactis CECT 8145 strain (marketed as PRIOME Metabolic Health or PRIOME MH) in both probiotic and heat-treated postbiotic forms, showing promise for supporting metabolic health in adult dogs.
Conducted in 45 healthy adult dogs, the double-blind, placebo-controlled study found a significant reduction in postprandial blood glucose levels in dogs receiving the postbiotic during the weight loss phase. The dogs were fed a standard kibble diet throughout the trial.
“These results mark an important step in advancing our understanding of the potential for postbiotics in metabolic health for pets, a health area that historically has been underserved by biotic ingredients,” said Sophie Nixon, Ph.D., head of R&D clinical research for pet and animal wellbeing at ADM. “With growing interest in functional ingredients for companion animals, our strain PRIOME MH in its postbiotic form offers exciting capabilities as a dietary supplement to help maintain metabolic health in adult dogs.”
The study included two phases: a weight gain phase, where dogs were overfed to induce weight gain, and a weight loss phase, where they were fed to meet maintenance levels for their ideal weight. Dogs were divided into three groups: one receiving the probiotic form, one receiving the postbiotic form, and a placebo group. Researchers measured blood glucose, gastrointestinal hormones, body composition, and liver markers, among other outcomes.
Additional results showed that dogs receiving the postbiotic had lower blood levels of gamma-glutamyl transferase (GGT) — a liver enzyme often elevated in obese dogs — during the weight gain phase.
“While postbiotics have long been recognized for their role in gut health, postbiotics like our strain PRIOME MH are emerging as innovative tools to support metabolic function and overall well-being in companion animals,” said Peter Jüsten, global vice president of R&D health and wellness at ADM. “These findings add to a growing body of research showing that postbiotics can have targeted physiological effects.”
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